Transcriptional regulation of the Ras-related protein TC21/R-Ras2 in endothelial cells.

@article{Kozian1997TranscriptionalRO,
  title={Transcriptional regulation of the Ras-related protein TC21/R-Ras2 in endothelial cells.},
  author={Dirk Kozian and Hellmut G Augustin},
  journal={FEBS letters},
  year={1997},
  volume={414 2},
  pages={239-42}
}
Applying an RNA display strategy to identify genes of autocrine activated endothelial cells, we identified among others the Ras-related protein TC21/R-Ras2 as a differentially expressed gene of bovine aortic endothelial cells (BAEC). Migrating BAEC express prominently upregulated steady state levels of TC21/R-Ras2 mRNA (Northern blot, in situ hybridization) and protein (Western blot). Growth factor stimulation identified TC21/R-Ras2 as aFGF, bFGF, and EGF inducible molecule of BAEC. Exposure to… CONTINUE READING