Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

@article{Aouabdi2005TranscriptionalRO,
  title={Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.},
  author={Sihem Aouabdi and Gordon G. Gibson and Nick D Plant},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={34 1},
  pages={
          138-44
        }
}
The pregnane X receptor (PXR, NR1I2) is widely regarded as a central factor in the body's response to changes in the fluxome, the overall metabolite profile in the body. PXR expression is regulated by a number of chemicals at the transcriptional level; the majority of these chemicals are ligands for PXR and substrates for PXR target genes. However, transcriptional activators of PXR, such as clofibrate, do not seem to be PXR ligands or substrates for its target genes. Understanding the molecular… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.

  • Archives of biochemistry and biophysics
  • 1999
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL