Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus.

@article{Bowser2002TranscriptionalRO,
  title={Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus.},
  author={Brian S. Bowser and Scott M Dewire and Blossom A Damania},
  journal={Journal of virology},
  year={2002},
  volume={76 24},
  pages={
          12574-83
        }
}
The K1 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) has been shown to be a transforming protein capable of inducing morphological changes and focus formation in rodent fibroblasts. K1 can activate B-cell receptor (BCR) signaling and upregulate activity of the NFAT and NF-kappaB transcription factors. In order to understand the regulation of K1 gene expression, we have analyzed sequences upstream of the K1 gene to identify the K1 promoter element. We have performed 5' rapid… CONTINUE READING

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