Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II.

@article{Raschke1999TranscriptionalRO,
  title={Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II.},
  author={Eva E Raschke and Thilo Albert and Dirk Eick},
  journal={Journal of immunology},
  year={1999},
  volume={163 8},
  pages={4375-82}
}
Transcriptional regulation can occur at the level of initiation and RNA elongation. We report that the rearranged, nontranscribed Ig kappa gene in the pre-B cell line 70Z/3 harbors a paused RNA polymerase II (pol II) at a position between 45 and 89 bp downstream of the transcription initiation site. LPS, an inducer of NF-kappa B, activated Ig kappa gene transcription by increasing the processivity of pol II. TGF-beta inhibited the LPS-induced transcription of the Ig kappa gene, but not… CONTINUE READING
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