Transcriptional regulation of the GnRH receptor gene by glucocorticoids

  title={Transcriptional regulation of the GnRH receptor gene by glucocorticoids},
  author={Guadalupe Maya-N{\'u}{\~n}ez and P. Michael Conn},
  journal={Molecular and Cellular Endocrinology},
Expression of the gonadotropin-releasing hormone (GnRH) receptor gene is stimulated by dexamethasone in GnRH-deficient rodents. In this study we identify a 1226 bp sequence at the 5'-flanking region of the mouse GnRH-R gene that confers dexamethasone responsiveness when expressed in host cells. Further, a glucocorticoid antagonist blocks transcriptional activity of the mGnRHR promoter. Progressive 5'-deletion of the mGnRHR promoter localized the response sequence between the -331/-255 region… CONTINUE READING


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