Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.

@article{Hess2007TranscriptionalRO,
  title={Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.},
  author={Norbert K Hess and Phillip A Singer and Kien T. Trinh and Massoud Nikkhoy and Sanford I Bernstein},
  journal={Gene expression patterns : GEP},
  year={2007},
  volume={7 4},
  pages={413-22}
}
We show that a 2.6kb fragment of the muscle myosin heavy-chain gene (Mhc) of Drosophila melanogaster (containing 458 base pairs of upstream sequence, the first exon, the first intron and the beginning of the second exon) drives expression in all muscles. Comparison of the minimal promoter to Mhc genes of 10 Drosophila species identified putative regulatory elements in the upstream region and in the first intron. The first intron is required for expression in four small cells of the tergal… CONTINUE READING