Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells

@article{Ito2011TranscriptionalRO,
  title={Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells},
  author={Takeshi Ito and Yuko Williams-Nate and Miwako Iwai and Yumi Tsuboi and Man Hagiyama and Akihiko Ito and Mika Sakurai-Yageta and Yoshinori Murakami},
  journal={Genes to Cells},
  year={2011},
  volume={16}
}
CADM1 is a multifunctional cell adhesion molecule expressed predominantly in the nerve system, testis and lung. The expression of the Cadm1 gene is induced during the neural differentiation of murine embryonal carcinoma P19 cells by treatment with retinoic acid (RA). Here, we show that the suppression of CADM1 expression using RNAi interfered with P19 cell aggregation and reduced cell populations expressing MAP2 after RA treatment. Nonaggregated P19 cells were not differentiated into neurons… 
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