Transcriptional regulation of the 230-kDa bullous pemphigoid antigen gene expression by interferon regulatory factor 1 and interferon regulatory factor 2 in normal human epidermal keratinocytes.

@article{Odanagi2004TranscriptionalRO,
  title={Transcriptional regulation of the 230-kDa bullous pemphigoid antigen gene expression by interferon regulatory factor 1 and interferon regulatory factor 2 in normal human epidermal keratinocytes.},
  author={Maiko Odanagi and Yasushi Kikuchi and Takehiko Yamazaki and Takahide Kaneko and Hajime Nakano and Katsuto Tamai and Jouni Uitto and Katsumi Hanada},
  journal={Experimental dermatology},
  year={2004},
  volume={13 12},
  pages={773-9}
}
Interferon regulatory factors (IRFs) are a family of transcriptional factors induced by interferon-gamma (IFN-gamma). Recent studies have indicated that the deregulation of IRF system in keratinocytes is responsible, at least in part, for aberrant proliferation and the differentiation of the psoriatic epidermis. Previously, we reported that the expression of 230-kDa bullous pemphigoid antigen (BPAG1) gene, which is strictly restricted to basal keratinocytes, is transcriptionally suppressed by… CONTINUE READING

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