Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.

@article{Fang2009TranscriptionalRO,
  title={Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.},
  author={Zhi Hong Fang and Chun Lan Dong and Zhong Chen and Bin Zhou and Na Liu and Hai Feng Lan and Lu Liang and Wen Bin Liao and Lei Zhang and Zhong Han},
  journal={Journal of cellular and molecular medicine},
  year={2009},
  volume={13 8B},
  pages={2039-52}
}
BCR/ABL can cause chronic myelogenous leukaemia (CML) in part by altering the transcription of specific genes with growth- and/or survival-promoting functions. Recently, BCR/ABL has been shown to activate survivin, an important regulator of cell growth and survival, but the precise molecular mechanisms behind its expression and consequences thereof in CML cells remain unclear. Here, we reported that BCR/ABL promotes survivin expression and its cytoplasmic accumulation. The increase of survivin… CONTINUE READING
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