Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.

@article{Yuasa2007TranscriptionalRO,
  title={Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.},
  author={Keizo Yuasa and Kaori Suzue and Masami Nagahama and Yoshifumi Matsuda and Akihiko Tsuji},
  journal={Gene},
  year={2007},
  volume={402 1-2},
  pages={
          103-10
        }
}
PACE4, a member of the subtilisin-like proprotein convertase (SPC) family, is expressed at high levels in certain tumor cells and plays a role in metastatic progression through activation of matrix metalloproteinases. The mechanism leading to overexpression of PACE4 in tumor cells remains unclear. In this study, we show that the E2F1 transcription factor, which is implicated in carcinoma invasiveness, upregulates the expression of PACE4. HT1080 (highly tumorigenic and invasive) cells expressed… CONTINUE READING
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