Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion.

@article{Legraverend1992TranscriptionalRO,
  title={Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion.},
  author={C Legraverend and Agneta Mode and Stu Westin and Anders Str{\"o}m and Hiroshi Eguchi and Peter G. Zaphiropoulos and J A Gustafsson},
  journal={Molecular endocrinology},
  year={1992},
  volume={6 2},
  pages={259-66}
}
The onset of the sexually dimorphic pattern of GH secretion and increased hepatic GH-binding capacity in rats at puberty is temporally correlated with the developmental induction of three hepatic cytochrome P-450s with steroid hydroxylase activity, P-450 IIC11, P-450 IIC12, and P-450 IIC13, and one cytochrome P-450 with vitamin A hydroxylase activity, P-450 IIC7. In this study we demonstrate that expression of the 2C11, 2C12, and 2C13 genes is modulated by GH at the level of transcriptional… CONTINUE READING