Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina

@article{Swaroop2010TranscriptionalRO,
  title={Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina},
  author={Anand Swaroop and Douglas S Kim and Douglas Forrest},
  journal={Nature Reviews Neuroscience},
  year={2010},
  volume={11},
  pages={563-576}
}
In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORβ, OTX2, NRL, CRX, NR2E3 and TRβ2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell… Expand
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TLDR
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Specification of Retinal Cell Types
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Development of neural and glial cell classes within the retina occurs in an overlapping, highly organized fashion and it is revealed that these cell classes differentiate from a common pool of multipotent progenitor cells, whose developmental potential shifts across embryonic and early postnatal life. Expand
Gene networks: Dissecting pathways in retinal development and disease
TLDR
An update on retinal development gene networks is provided and the wider implications for future disease therapeutics are addressed. Expand
Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor development
TLDR
It is shown that Otx2 and Oc1 directly regulate the activity of multiple CRMs genome-wide, including near genes important for cone development, such as Rxrg and Neurod1. Expand
Prediction of Transcriptional Regulatory Networks for Retinal Development
TLDR
A new method for the computational analysis of TFBSs and transcriptional regulatory networks utilizing genome-wide sequencing, expression, and enhancer data is presented and it is shown that a regulatory cascade can be recognized via consequential analysis of the factors involved. Expand
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