Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats.

@article{Krasinski1994TranscriptionalRO,
  title={Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats.},
  author={Stephen D. Krasinski and Garnica Estrada and Kwo-yih Yeh and Mary Yeh and Peter G. Traber and Edmond H. H. M. Rings and Hans A. B{\"u}ller and Menno Verhave and Robert K. Montgomery and Richard J. Grand},
  journal={The American journal of physiology},
  year={1994},
  volume={267 4 Pt 1},
  pages={G584-94}
}
Lactase-phlorizin hydrolase (LPH) and sucrase-isomaltase (SI) are intestine-specific microvillus membrane hydrolases whose specific activities demonstrate reciprocal regulation during development but whose mechanisms of regulation have not been fully defined. To investigate transcriptional control of these two proteins, the rat LPH and SI genes were cloned, and antisense probes for preprocessed mRNAs (pre-mRNAs) were developed from intron sequence. LPH mRNA, as measured by quantitative… CONTINUE READING