Transcriptional regulation of interleukin-3 expression in megakaryocytes.

@article{Nimer1996TranscriptionalRO,
  title={Transcriptional regulation of interleukin-3 expression in megakaryocytes.},
  author={Stephen Nimer and Jin Zhang and Hava Karsenty Avraham and Yasushi Miyazaki},
  journal={Blood},
  year={1996},
  volume={88 1},
  pages={66-74}
}
Interleukin-3 (IL-3) is a potent stimulator of megakaryocyte proliferation, and autocrine production of IL-3 by megakaryocytic leukemia cell lines and bone marrow-derived megakaryocytes has recently been demonstrated. To characterize the transcriptional regulation of IL-3 in megakaryocytes, we transiently transfected IL-3 promoter CAT constructs that contain variable amounts of 5' flanking sequences into the human CMK and CMK-6 megakaryocytic cell lines and identified two positive acting… CONTINUE READING

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Showing 1-10 of 64 references

Current Protocols in Molecular Biology

  • FM Ausubel, R Brent, +4 authors K Struhl
  • Greene Publishing Associates and Wiley…
  • 1995

Molecular cloning and characterization of NF-IL3A; A transcriptional activator of the human IL-3 promoter

  • W Zhang, J Zhang, M Komuc, K Kwan, R Frank, SD Nimer
  • Mol Cell Biol
  • 1995

Zucker - Franklin D , Lofton - Day C : Thrombopoietin , the Mpl ligand , is essential for full megakaryocyte development

  • RM Schmitt, E Bruyns, HR Snodgrass
  • Proc Natl Acad Sci USA
  • 1995

Characterization of a cell-type-restricted negative regulatory activity of the human granulocyte-macrophage colony-stimulating factor gene

  • SD NlMER ET AL Nimer
  • Mol Cell Biol
  • 1994

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

  • GJ, DC Foster
  • Nature 369:565,
  • 1994

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