Transcriptional regulation of interleukin-3 expression in megakaryocytes.

  title={Transcriptional regulation of interleukin-3 expression in megakaryocytes.},
  author={Stephen Nimer and Jin Zhang and Hava Karsenty Avraham and Yasushi Miyazaki},
  volume={88 1},
Interleukin-3 (IL-3) is a potent stimulator of megakaryocyte proliferation, and autocrine production of IL-3 by megakaryocytic leukemia cell lines and bone marrow-derived megakaryocytes has recently been demonstrated. To characterize the transcriptional regulation of IL-3 in megakaryocytes, we transiently transfected IL-3 promoter CAT constructs that contain variable amounts of 5' flanking sequences into the human CMK and CMK-6 megakaryocytic cell lines and identified two positive acting… CONTINUE READING


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