Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-κB and activator protein-1.

@article{Deng2013TranscriptionalRO,
  title={Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-κB and activator protein-1.},
  author={Xiaoling Deng and Mingyan Xu and Chao Yuan and Liqin Yin and Xihe Chen and Xiaoqiong Zhou and Guanwu Li and Yucai Fu and Carol Feghali-Bostwick and Linhua Pang},
  journal={The international journal of biochemistry & cell biology},
  year={2013},
  volume={45 7},
  pages={1366-76}
}
Chemokine (CC motif) ligand-2 (CCL2) is a member of C-C chemokine superfamily that contributes to inflammatory and fibrotic process. Studies in patients and experimental animals provide compelling evidence that increased CCL2 expression plays an important role in the development of fibroproliferative lung disease. The up-regulated CCL2 expression in pulmonary fibrosis is also involved in the potent profibrotic effects that thrombin exerts during lung injury. Here, we investigated the… CONTINUE READING

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