Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland: day/night changes and long-term effects of light and darkness.

@article{Bernard1993TranscriptionalRO,
  title={Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland: day/night changes and long-term effects of light and darkness.},
  author={Marianne Bernard and J{\'e}r{\^o}me Guerlott{\'e} and Michel Cogn{\'e} and Pierre Gr{\`e}ve and Jean Pierre Collin and Pierre J Voisin},
  journal={The Biochemical journal},
  year={1993},
  volume={290 ( Pt 3)},
  pages={661-4}
}
The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with… CONTINUE READING

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The terminal step of melatonin synthesis is catalysed by hydroxyindole O - methyltransferase ( HIOMT , EC 2.1.1.4 ) .
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