Transcriptional regulation of human UDP-glucuronosyltransferase genes.

@article{Hu2014TranscriptionalRO,
  title={Transcriptional regulation of human UDP-glucuronosyltransferase genes.},
  author={Dong Gui Hu and Robyn Meech and Ross A. McKinnon and Peter I. Mackenzie},
  journal={Drug metabolism reviews},
  year={2014},
  volume={46 4},
  pages={421-58}
}
Glucuronidation is an important metabolic pathway for many small endogenous and exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids, carcinogens and therapeutic drugs. Glucuronidation is primarily catalyzed by the UDP-glucuronosyltransferase (UGT) 1A and two subfamilies, including nine functional UGT1A enzymes (1A1, 1A3-1A10) and 10 functional UGT2 enzymes (2A1, 2A2, 2A3, 2B4, 2B7, 2B10, 2B11, 2B15, 2B17 and 2B28). Most UGTs are expressed in the liver and this… CONTINUE READING

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