Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4.

  title={Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4.},
  author={Kyoko Ochiai and Mark Maienschein-Cline and Giorgia Simonetti and Jianjun Chen and Rebecca Rosenthal and Robert Brink and Anita S Chong and Ulf Klein and Aaron R. Dinner and Harinder Singh and Roger Sciammas},
  volume={38 5},
The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation. Its differing concentrations appear to regulate mutually antagonistic programs of B and plasma cell gene expression. We show IRF4 to be also required for generation of germinal center (GC) B cells. Its transient expression in vivo induced the expression of key GC genes including Bcl6 and Aicda. In contrast, sustained and higher concentrations of IRF4 promoted the generation of… CONTINUE READING
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Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4, Immunity

  • Ochiai
  • 2013
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