Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

  title={Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.},
  author={Gregg L Semenza and Peter H. Roth and Hui Fang and Gexin Wang},
  journal={The Journal of biological chemistry},
  volume={269 38},
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas… CONTINUE READING
Highly Influential
This paper has highly influenced 42 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 546 extracted citations

The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2012
View 6 Excerpts
Highly Influenced

Adrenomedullin promotes human endothelial cell proliferation via HIF-1α

Molecular and Cellular Biochemistry • 2012
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.

Eur : ( 1987 )

R. Zielinski, C. Boyd, A. Dugaiczyk
J . Mol . Biol • 1990

Similar Papers

Loading similar papers…