Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

@article{Semenza1994TranscriptionalRO,
  title={Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.},
  author={Gregg L Semenza and Peter H. Roth and Hui Fang and Gexin Wang},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 38},
  pages={23757-63}
}
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas… CONTINUE READING
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