Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells.

  title={Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells.},
  author={Stephanie Harkey Shirley and Joyce E. Rundhaug and Jie Tian and Noirin Cullinan-Ammann and Isabel U Lambertz and Claudio J. Conti and Robin Fuchs-Young},
  journal={Cancer research},
  volume={69 8},
Estrogen receptor alpha (ER) and p53 are critical prognostic indicators in breast cancer. Loss of functional p53 is correlated with poor prognosis, ER negativity, and resistance to antiestrogen treatment. Previously, we found that p53 genotype was correlated with ER expression and response to tamoxifen in mammary tumors arising in mouse mammary tumor virus-Wnt-1 transgenic mice. These results lead us to hypothesize that p53 may regulate ER expression. To test this, MCF-7 cells were treated with… CONTINUE READING


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The tumor suppressor p53 is a negative regulator of estrogen receptor signaling Transcriptional Regulation of ERa in Breast Cancer Cells 3413

  • CL Yu, P Driggers, G Barrera-Hernandez, SB Nunez, JH Segars, S. Cheng
  • Cancer Res
  • 2009

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