Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements.

@article{Perry2002TranscriptionalRO,
  title={Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements.},
  author={Chava Perry and Hermona Soreq},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 15},
  pages={3607-18}
}
Haematopoiesis, the differentiation of haematopoietic stem cells and progenitors into various lineages, involves complex interactions of transcription factors that modulate the expression of downstream genes and mediate proliferation and differentiation signals. Commitment of pluripotent haematopoietic stem cells to the erythroid lineage induces erythropoiesis, the production of red blood cells. This process involves a concerted progression through an erythroid burst forming unit (BFU-E), an… CONTINUE READING
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