Transcriptional regulation of endothelial cell and vascular development.

  title={Transcriptional regulation of endothelial cell and vascular development.},
  author={Changwon Park and Tae Min Kim and Asrar B. Malik},
  journal={Circulation research},
  volume={112 10},
The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the pathogenesis of vascular diseases. Here, we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling… CONTINUE READING

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