Transcriptional regulation of angiotensinogen gene expression.

  title={Transcriptional regulation of angiotensinogen gene expression.},
  author={Allan R. Brasier and Ying Han and Christopher T. Sherman},
  journal={Vitamins and hormones},
The renin--angiotensin system (RAS) is an extracellular hormonal system implicated in acute, homeostatic control of peripheral vascular resistance and electrolyte homeostasis. In this tightly regulated system, physiological regulators of blood pressure and fluid balance induce the production of the potent vasoactive angiotensin peptides by sequential proteolysis of the angiotensinogen (AGT) prohormone. AGT is the only known precursor of the angiotensin peptides, whose circulating concentrations… CONTINUE READING


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