Transcriptional regulation of T cell tolerance.

@article{Bandyopadhyay2007TranscriptionalRO,
  title={Transcriptional regulation of T cell tolerance.},
  author={Sanmay Bandyopadhyay and Noem{\'i} Soto-Nieves and Fernando Macian},
  journal={Seminars in immunology},
  year={2007},
  volume={19 3},
  pages={
          180-7
        }
}
Self-reactive T cells that escape negative selection in the thymus must be kept under control in the periphery. Mechanisms of peripheral tolerance include deletion or functional inactivation of self-reactive T cells and mechanisms of dominant tolerance mediated by regulatory T cells. In the absence of costimulation, T cell receptor (TCR) engagement results in unopposed calcium signaling that leads to the activation of a cell-intrinsic program of inactivation, which makes T cells hyporesponsive… CONTINUE READING

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