Transcriptional regulation of RANTES expression in T lymphocytes

@article{Song2000TranscriptionalRO,
  title={Transcriptional regulation of RANTES expression in T lymphocytes},
  author={An Song and Tania Nikolcheva and Alan M. Krensky},
  journal={Immunological Reviews},
  year={2000},
  volume={177}
}
We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes "late", 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such "late" expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late… 

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TLDR
The results reveal a developmental switch occurring during normal T-cell maturation coincident with the onset of terminal differentiation and the binding of late-acting factors to sequences of the RANTES promoter.

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TLDR
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It is hypothesize that these apparently novel proteins are responsible in part for the temporal regulation of RANTES seen in peripheral blood T cells and represent a component of transcriptional regulatory machinery newly expressed at this "late" stage of peripheral T cell development.

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TLDR
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TLDR
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TLDR
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TLDR
Functional analyses of RantES promoter activity indicated that the RANTES-28G mutation increases RANTes expression in HIV-1-infected individuals and thus delays the progression of the HIV- 1 disease.
...