Transcriptional regulation of RANTES expression in T lymphocytes

  title={Transcriptional regulation of RANTES expression in T lymphocytes},
  author={An Song and Tania Nikolcheva and Alan M. Krensky},
  journal={Immunological Reviews},
We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes "late", 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such "late" expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late… 

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.

It is demonstrated that RFLAT-1 expression is translationally regulated through its 5'-UTR and in a cell type-specific manner, providing a molecular mechanism for a rheostat effect of increasing or decreasing RANTES expression at sites of inflammation.

Mechanisms of Disease: regulation of RANTES (CCL5) in renal disease

Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues and have major implications for the rational design of drugs aimed at increasing or decreasing inflammatory responses in patients.

Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.

Krüppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo1

Microarray analysis suggests that protection from apoptosis-inducing stimuli in Klf13−/− thymocytes is due in part to increased expression of BCL-XL, a potent antiapoptotic factor.

Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.

RANTES and CCR5 represent potential mediators of HSC migration and proliferation and a cross-talk between HSCs and leukocytes during fibrogenesis, indicating that NADPH oxidase-dependent production of reactive oxygen species was required.

Analysis of Transcription Factor Expression during Discrete Stages of Postnatal Thymocyte Differentiation1

A large number of transcription factors to be expressed in developing T lymphocytes, including many with known roles in the control of differentiation, proliferation, or cell survival/death decisions in other cell types are found.

Thymocyte Differentiation during Discrete Stages of Postnatal Analysis of Transcription Factor Expression

High density microarrays were used to analyze transcription factor gene expression in RNA derived from progenitors at each stage of T lymphopoietic differentiation, and the results were validated by a number of appropriate methods.

Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells.

DSRNA selectively induce the secretion of chemokines such as IL-8 and RANTES, and implicate dsRNA-sensitive signaling proteins in this process, suggesting that this may be an important mechanism for the selective secretion of Chemokines by viruses that synthesize ds RNA during replication.



Kinetics of transcription factors regulating the RANTES chemokine gene reveal a developmental switch in nuclear events during T-lymphocyte maturation

The results reveal a developmental switch occurring during normal T-cell maturation coincident with the onset of terminal differentiation and the binding of late-acting factors to sequences of the RANTES promoter.

Genomic organization and transcriptional regulation of the RANTES chemokine gene.

Deletion analysis of the promoter region indicates that different transcriptional mechanisms control expression of RANTES in the various tissues studied, and this work characterized the RantES gene and determined a putative promoter region.

Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.

NF-kappa B, a potent transcriptional activator of HIV expression, is also involved in the expression of RANTES, a chemokine that blocks infection by macrophage-tropic strains of HIV.

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

It is demonstrated that endogenous human RANTES gene transcription is directly induced in tetracycline-inducible IRF-3(5D)-expressing cells or paramyxovirus-infected cells and it is shown that a dominant-negative IRf-3 mutant inhibits virus-induced expression of the RantES promoter.

Switching gears during T-cell maturation: RANTES and late transcription.

Activation of dual T cell signaling pathways by the chemokine RANTES.

In addition to inducing chemotaxis, RANTES can act as an antigen-independent activator of T cells in vitro, and was associated with a spectrum of cellular responses--Ca2+ channel opening, interleukin-2 receptor expression, cytokine release, and T cell proliferation--characteristic of T cell receptor activation.

A human T cell-specific molecule is a member of a new gene family.

There is significant homology between the RANTES sequence and several other T cell genes, suggesting that they comprise a previously undescribed family of small T cell molecules.

Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

  • H. LiuD. Chao T. Shioda
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Functional analyses of RantES promoter activity indicated that the RANTES-28G mutation increases RANTes expression in HIV-1-infected individuals and thus delays the progression of the HIV- 1 disease.

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

The RANTES protein3 of the C-C class causes the selective migration of human blood monocytes and of T lymphocytes expressing the cell surface antigens CD4 and UCHL1, and may provide insight into the workings of T cell memory.