Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila.

@article{Seugnet1997TranscriptionalRO,
  title={Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila.},
  author={Laurent Seugnet and Peter A. Simpson and M Haenlin},
  journal={Development},
  year={1997},
  volume={124 10},
  pages={2015-25}
}
Segregation of a single neural precursor from each proneural cluster in Drosophila relies on Notch-mediated lateral signalling. Studies concerning the spacing of precursors for the microchaetes of the peripheral nervous system suggested the existence of a regulatory loop between Notch and its ligand Delta within each cell that is under transcriptional control. Activation of Notch leads to repression of the achaete-scute genes which themselves regulate transcription of Delta, perhaps directly… CONTINUE READING