Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

Abstract

INTRODUCTION L-type calcium channel (LTCC) activity in the brain is mediated by 2 subtypes, Ca(v)1.2 and Ca(v)1.3. The individual contributions of these LTCC subtypes to the long-term pharmacological and behavioral effects of nicotine are unknown. METHODS Using quantitative in situ hybridization, we examined expression levels of Ca(v)1.2 and Ca(v)1.3 in… (More)
DOI: 10.1093/ntr/ntt274

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