Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein

@article{Finkeltov2002TranscriptionalRO,
  title={Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein},
  author={Ina Finkeltov and Scott E Kuhn and Tova Glaser and Gila Idelman and John Joseph Wright and Charles Roberts and Haim Werner},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1890-1898}
}
The EWS family of genes is involved in numerous chromosomal translocations that are characteristic of a variety of sarcomas. A recently described member of this group is desmoplastic small round cell tumor (DSRCT), which is characterized by a recurrent t(11;22)(p13;q12) translocation that fuses the 5′ exons of the EWS gene to the 3′ exons of the WT1 gene. The originally described chimera comprises exons 1–7 of EWS and exons 8–10 of WT1. We have previously reported that the WT1 protein represses… CONTINUE READING

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