Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses.

@article{Xiu2002TranscriptionalRO,
  title={Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses.},
  author={Yan Xiu and Kazuhiro Nakamura and Masaaki Abe and Na Li and Xiang Shu Wen and Yi Jiang and Danqing Zhang and Hiromichi Tsurui and Shuji Matsuoka and Yoshitomo Hamano and Hiroyuki Fujii and Masao Ono and Toshiyuki Takai and Toshibumi Shimokawa and Chisei Ra and Toshikazu Shirai and S. Hirose},
  journal={Journal of immunology},
  year={2002},
  volume={169 8},
  pages={4340-6}
}
FcgammaRIIB1 molecules serve as negative feedback regulator for B cell Ag receptor-elicited activation of B cells; thus, any impaired FcgammaRIIB1 function may possibly be related to aberrant B cell activation. We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains in which systemic autoimmune disease-prone NZB, BXSB, MRL, and autoimmune diabetes-prone nonobese diabetic, but not NZW, BALB/c, and C57BL/6 mice have two identical deletion sites, consisting of 13… CONTINUE READING

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Genetic basis of systemic lupus erythematosus

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