Transcriptional regulation of FGF-2 gene expression in cardiac myocytes.

@article{Jimenez2004TranscriptionalRO,
  title={Transcriptional regulation of FGF-2 gene expression in cardiac myocytes.},
  author={Sarah K. Jimenez and F. Sheikh and Y. Jin and K. Detillieux and J. Dhaliwal and E. Kardami and P. Cattini},
  journal={Cardiovascular research},
  year={2004},
  volume={62 3},
  pages={
          548-57
        }
}
OBJECTIVE Fibroblast growth factor-2 (FGF-2) exerts its cardioprotective effect through cell surface receptor signaling and may play a role in the normal maintenance of a healthy myocardium. One mechanism of FGF-2 release from contracting cardiomyocytes is through transient sarcolemmal disruption, with accumulation in the extracellular matrix. Continuous FGF-2 release would require a link to synthesis and, thus, we examined regulation of FGF-2 promoter activity in cardiomyocytes as a potential… Expand
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