Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.

Abstract

Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly known. In previous work, we have shown that CYP2C9 is inducible in primary human hepatocytes by xenobiotics including dexamethasone, rifampicin, and phenobarbital. The aim of this work was to investigate the molecular mechanism(s… (More)

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Cite this paper

@article{Gerbalchaloin2002TranscriptionalRO, title={Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.}, author={Sabine Gerbal-chaloin and Martine Daujat and Jean Marc Pascussi and Lydiane Pichard-Garcia and M. C. Vilarem and Patrick Maurel}, journal={The Journal of biological chemistry}, year={2002}, volume={277 1}, pages={209-17} }