Transcriptional regulation of α-cell differentiation.

  title={Transcriptional regulation of α-cell differentiation.},
  author={Nuria C. Bramswig and Klaus H. Kaestner},
  journal={Diabetes, obesity & metabolism},
  volume={13 Suppl 1},
The development of the endocrine pancreas and the differentiation of its five cell types, α, β, δ, ε and pancreatic polypeptide (PP) cells, are a highly complex and tightly regulated process. Proper differentiation and function of α- and β-cells are critical for blood glucose homeostasis. These processes are governed by multiple transcription factors and other signalling systems, and its dysregulation results in diabetes. The differentiation of α-cells and the maintenance of α-cell function can… CONTINUE READING
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