Transcriptional regulation in early B cell development.

  title={Transcriptional regulation in early B cell development.},
  author={Martin Fuxa and Jane A. Skok},
  journal={Current opinion in immunology},
  volume={19 2},
Transcription factors and signalling molecules are important for both lineage commitment and lineage-specific regulation. The B cell specification factor Pax5 plays a dual role in B lineage commitment. Simultaneously, it potentiates and limits lineage choice by activating genes that are required for the B cell program while repressing lineage-inappropriate genes; more than 100 of the latter have now been identified. In this context, repression of the tyrosine kinase Flt3 has been shown to be… CONTINUE READING