Transcriptional regulation by the gamma5 subunit of a heterotrimeric G protein during adipogenesis.

@article{Park1999TranscriptionalRB,
  title={Transcriptional regulation by the gamma5 subunit of a heterotrimeric G protein during adipogenesis.},
  author={Jin Gyoon Park and Aleixo M Muise and G. P. He and Sang Wan Kim and H S Ro},
  journal={The EMBO journal},
  year={1999},
  volume={18 14},
  pages={4004-12}
}
The adipocyte enhancer-binding protein (AEBP1) is a novel transcriptional repressor with carboxypeptidase activity. A two-hybrid screen was conducted to identify components of AEBP1 that might be important in regulating its activity. The gamma5 subunit of a heterotrimeric G protein was shown to bind specifically to AEBP1 and to attenuate its transcriptional repression activity. Adipogenic stimulation selectively decreased the Ggamma5 level and enhanced the transcriptional repression activity of… CONTINUE READING
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