Transcriptional regulation by the phosphorylation-dependent factor CREB

@article{Mayr2001TranscriptionalRB,
  title={Transcriptional regulation by the phosphorylation-dependent factor CREB},
  author={Bernhard M Mayr and Marc Montminy},
  journal={Nature Reviews Molecular Cell Biology},
  year={2001},
  volume={2},
  pages={599-609}
}
  • B. Mayr, M. Montminy
  • Published 1 August 2001
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
The transcription factor CREB ? for 'cyclic AMP response element-binding protein' ? functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways? 

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References

SHOWING 1-10 OF 122 REFERENCES
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
TLDR
Findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors. Expand
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
TLDR
Findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses. Expand
Phosphorylated CREB binds specifically to the nuclear protein CBP
TLDR
It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7. Expand
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
TLDR
Findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression. Expand
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
TLDR
It is reported here that micro-injection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter, and proposed that CBP is recruited to the promoter through interaction with certain phosphorylated factors, and may thus play a critical role in the transmission of inductive signals from cell surface receptor to the transcriptional apparatus. Expand
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
TLDR
The isolation of a cDNA clone for rat CREB is reported using amino-acid sequence information from purified CREB protein, which predicts a cluster ofprotein kinase A, protein kinase C and casein kinase II consensus recognition sites near the N terminus of the protein that may interact either positively or negatively to regulate CREB bioactivity. Expand
Insulin-like Growth Factor I-mediated Activation of the Transcription Factor cAMP Response Element-binding Protein in PC12 Cells
TLDR
This is the first description of a p38 MAPK-mediated nuclear signaling pathway for IGF-I leading to CREB-dependent neuronal specific gene expression in rat pheochromocytoma cells. Expand
Distinct cAMP response element-binding protein (CREB) domains stimulate different steps in a concerted mechanism of transcription activation.
  • J. Kim, J. Lu, P. G. Quinn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
The results provide evidence for a new model for CREB-mediated induction through a concerted mechanism involving establishment of a polymerase complex by the CAD, followed by stimulation of isomerization, promoter clearance, and/or reinitiation by phosphorylated KID to enhance target gene transcription. Expand
Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.
TLDR
The results suggest that the recruitment of CBP-RNA Pol II complexes per se is not sufficient for transcriptional activation and that activator-mediated recruitment of TFIID is additionally required for induction of signal-dependent genes. Expand
The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex.
TLDR
It is demonstrated that Q2 functions as a potent constitutive activator in vitro, and the results suggest that transcriptionally inactive CREM alpha and beta proteins may repress transcription because they are unable to interact with the basal transcription complex. Expand
...
1
2
3
4
5
...