Transcriptional regulation by steroid hormones

@article{Beato1996TranscriptionalRB,
  title={Transcriptional regulation by steroid hormones},
  author={Miguel Beato and Sebasti{\'a}n Ch{\'a}vez and Mathias Truss},
  journal={Steroids},
  year={1996},
  volume={61},
  pages={240-251}
}

The Androgen Receptor Amino-Terminal Domain Plays a Key Role in p160 Coactivator-Stimulated Gene Transcription

The functional interactions between the androgen receptor (AR) and 160-kDa nuclear receptor coactivators are analyzed and suggest that in the native AR the efficient recruitment of coactivator requires a functional association of the NTD with the LBD and that the binding of coActivators occurs primarily through the N TD.

Glucocorticoid Receptor Structure and Function

A molecular map that integrates site-specific DNA, ligands, chromatin, coregulators and post-transcriptional modifications to determine the composition and function of gene-specific transcriptional regulatory complexes involving glucocorticoid receptor modulators is proposed.

Interaction between the Retinoid X Receptor and Transcription Factor IIB Is Ligand-dependent in Vivo *

Functional analysis and co-immunoprecipitation, far Western analysis, and glutathioneS-transferase binding studies indicate that interaction of mRXRβ with TFIIB is specific, direct, and ligand-dependent in vivo and suggest that gene activation by RXR involvesTFIIB.

Auto-silencing by the retinoid X receptor.

It is proposed that RXR acts as an auto-silencer by sequestering itself into tetramers, and that an important role for the ligand in activating this receptor is to release active species, dimers and monomers, from the transcriptionally inactive tetrameric pool.

The Classic Steroid Hormone Receptors and ERβ, the Novel Estrogen Receptor

Immunocytochemical studies with monoclonal antibodies against the various receptors indicate that most steroid hormone receptors (e.g., ER and PR) are nuclear even in the absence of hormone, although GR and MR appear to be exceptions.

Choosing the right partner in hormone-dependent gene regulation: Glucocorticoid and progesterone receptors crosstalk in breast cancer cells

The state of the art of the functional cross-talk between PR and GR in breast cancer cells is summarized and new paradigms of specificity in hormone action are discussed.

Potentiation of glucocorticoid receptor transcriptional activity by sumoylation.

A model in which SUMO-1 regulates the synergy control function of GR and serves as a unique signal for activation and destruction is proposed, largely exceeding those observed so far for other sumoylated transcription factors.

Rapid steroid hormone actions via membrane receptors.

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