Transcriptional regulation by steroid hormones

  title={Transcriptional regulation by steroid hormones},
  author={M. Beato and S. Ch{\'a}vez and M. Truss},
  • M. Beato, S. Chávez, M. Truss
  • Published 1996
  • Chemistry, Medicine
  • Steroids
  • Steroid hormones influence the transcription of a large number of genes by virtue of their interaction with intracellular receptors, which are modular proteins composed of a ligand binding domain, a DNA binding domain, and several transactivation functions distributed along the molecule. The DNA binding domain is organized around two zinc ions and allows the receptors to bind as homodimers to palindromic DNA sequences, the hormones responsive elements (HRE), is such a way that each homodimer… CONTINUE READING
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