Transcriptional regulation by p53. Functional interactions among multiple regulatory domains.

@article{Hsu1995TranscriptionalRB,
  title={Transcriptional regulation by p53. Functional interactions among multiple regulatory domains.},
  author={Yen Sheng Hsu and F M Tang and W. L. Liu and Johnson Chuang and Miao Y Lai and Young Sun Lin},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 12},
  pages={6966-74}
}
The tumor suppressor p53 protein possesses activities typical of eukaryotic transcriptional activators; p53 binds to specific DNA sequences and stimulates transcription of the target genes. By a series of deletion and domain-swapping studies, we report here that (i) p53 has two auxiliary domains, which have little effect on the DNA binding activity of its… CONTINUE READING