Transcriptional regulation by nonclassical action of thyroid hormone

  title={Transcriptional regulation by nonclassical action of thyroid hormone},
  author={Lars Christian Moeller and Martina Broecker-Preuss},
  booktitle={Thyroid research},
Thyroid hormone (TH) is essential for normal development, growth and metabolism. Its effects were thought to be principally mediated through triiodothyronine (T3), acting as a ligand for the nuclear TH receptors (TRs) α and β residing on thyroid hormone response elements (TREs) in the promoter of TH target genes. In this classical model of TH action, T3 binding to TRs leads to recruitment of basal transcription factors and increased transcription of TH responsive genes.Recently, the concept of… CONTINUE READING
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