Transcriptional regulation by nicotine in dopaminergic neurons.

  title={Transcriptional regulation by nicotine in dopaminergic neurons.},
  author={B. Henley and Brian A. Williams and Rahul Srinivasan and Bruce N Cohen and Cheng Xiao and Elisha D. W. Mackey and Barbara J. Wold and Henry A. Lester},
  journal={Biochemical pharmacology},
  volume={86 8},
Dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate in Parkinson's disease. These neurons robustly express several nicotinic acetylcholine receptor (nAChR) subtypes. Smoking appears to be neuroprotective for Parkinson's disease but the mechanism is unknown. To determine whether chronic nicotine-induced changes in gene expression contribute to the neuroprotective effects of smoking, we develop methods to measure the effect of prolonged nicotine exposure on the SNc… CONTINUE READING
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