Transcriptional regulation by cyclic AMP.

  title={Transcriptional regulation by cyclic AMP.},
  author={Marc R. Montminy},
  journal={Annual review of biochemistry},
A number of hormones and growth factors have been shown to stimulate target cells via second messenger pathways that in turn regulate the phosphorylation of specific nuclear factors. The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including intermediary metabolism, cellular proliferation, and neuronal signaling, by altering basic patterns of gene expression. Our understanding of cyclic AMP signaling in the nucleus has expanded considerably… CONTINUE READING
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