[Transcriptional regulation by cAMP and calcium].

  • Masaki Hagiwara
  • Published 1996 in
    Nihon yakurigaku zasshi. Folia pharmacologica…


Transcription of a number of eukaryotic genes is activated in response to an increase in the intracellular cAMP concentration. These genes stimulated by cAMP have a common promoter element, cAMP response element (CRE). The CRE is recognized by a CRE binding protein, CREB. The binding of CREB to CRE does not induce transcription. Activation of transcription requires the phosphorylation or CREB at Ser-133. In the case of the cAMP pathway, the activated catalytic subunit of cAMP-dependent protein kinase (PKA) translocates to the nucleus and phosphorylates Ser-133 of CREB. In the nervous system, signals transmitted across synapses are known to regulate gene expression in the post-synaptic cell. This process often involves membrane depolarization and subsequent amplification of intracellular Ca2+. The transcriptional activation induced by membrane depolarization and Ca2+ influx is mediated by a promoter element, called the Ca(2+)-responsive element (CaRE). Recent studies of c-fos and proenkephalin gene expression have shown that the CaRE is indistinguishable from a CRE. In this paper, we focus on the possible interactions between Ca2+ and the cAMP signaling pathways into the nucleus.

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@article{Hagiwara1996TranscriptionalRB, title={[Transcriptional regulation by cAMP and calcium].}, author={Masaki Hagiwara}, journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica}, year={1996}, volume={107 2}, pages={47-52} }