Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway

@inproceedings{AuYeung2013TranscriptionalRB,
  title={Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway},
  author={Nancy Au-Yeung and Roli Mandhana and Curt M Horvath},
  booktitle={JAK-STAT},
  year={2013}
}
STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. They associate with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as ISGF3. The regulation of IFN-stimulated gene (ISG) expression has served as a model of JAK-STAT signaling and mammalian transcriptional regulation, but to date has primarily been analyzed at the single… CONTINUE READING

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