Transcriptional regulation by Polycomb group proteins

@article{Croce2013TranscriptionalRB,
  title={Transcriptional regulation by Polycomb group proteins},
  author={Luciano Di Croce and Kristian Helin},
  journal={Nature Structural &Molecular Biology},
  year={2013},
  volume={20},
  pages={1147-1155}
}
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and… CONTINUE READING
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