Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation

  title={Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation},
  author={Luis Carlos Saenz and Juan Jos{\'e} Lozano and Rut Valdor and Alberto Baroja-Mazo and Pablo Ram{\'i}rez and Pascual Parrilla and Pedro Aparicio and Lauro Sumoy and Jos{\'e} Y{\'e}lamos},
  journal={BMC Genomics},
  pages={171 - 171}
Accumulating evidence suggests an important role for the enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as an integral part of the gene expression regulatory machinery during development and in response to specific cellular signals. PARP-1 might modulate gene expression through its catalytic activity leading to poly(ADP-ribosyl)ation of nuclear proteins or by its physical association with relevant proteins. Recently, we have shown that PARP-1 is activated during T cell activation. However, the… CONTINUE READING