Transcriptional regulation by MAP kinases

@article{Davis1995TranscriptionalRB,
  title={Transcriptional regulation by MAP kinases},
  author={Roger J. Davis},
  journal={Molecular Reproduction and Development},
  year={1995},
  volume={42}
}
  • R. Davis
  • Published 1 December 1995
  • Biology, Computer Science
  • Molecular Reproduction and Development
Tyrosine kinase growth factor receptors activate MAP kinase by a complex mechanism involving the SH2/3 protein Grb2, the exchange protein Sos, and Ras. The GTP‐bound Ras protein binds to the Raf kinase and initiates a protein kinase cascade that leads to MAP kinase activation. Three MAP kinase kinase kinases have been described‐c‐Raf, c‐Mos, and Mekk—that phosphorylate and activate Mek, the MAP kinase kinase. Activated Mek phosphorylates and activates MAP kinase. Subsequently, the activated MAP… 
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