Transcriptional regulation and structural organization of the human cytosolic phospholipase A(2) gene.

@article{DolanOkeefe2000TranscriptionalRA,
  title={Transcriptional regulation and structural organization of the human cytosolic phospholipase A(2) gene.},
  author={M Dolan-O'keefe and Vivian Deh-Wei Chow and Justin Monnier and Gary A. Visner and Harry S. Nick},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={278 4},
  pages={L649-57}
}
Cytokines are established regulators of the arachidonic acid cascade in lung cells. The levels of various arachidonic metabolites distinguish the normal and pathogenic states of the human lung. Arachidonyl-selective cytosolic phospholipase A(2) (cPLA(2)) is ubiquitously present in human lung and is most likely the rate-limiting step in eicosanoid generation… CONTINUE READING