Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors.

@article{Ng2003TranscriptionalRA,
  title={Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors.},
  author={Wai-Leung Ng and Krystyna M. Kazmierczak and Gregory T. Robertson and Raymond Gilmour and Malcolm E Winkler},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 1},
  pages={359-70}
}
The effects of sublethal concentrations of four different classes of translation inhibitors (puromycin, tetracycline, chloramphenicol, and erythromycin) on global transcription patterns of Streptococcus pneumoniae R6 were determined by microarray analyses. Consistent with the general mode of action of these inhibitors, relative transcript levels of genes that encode ribosomal proteins and translation factors or that mediate tRNA charging and amino acid biosynthesis increased or decreased… CONTINUE READING
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