Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae.

@article{Rioux2011TranscriptionalRO,
  title={Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae.},
  author={St{\'e}phane Rioux and Cecile Anne Neyt and Emmanuel Di Paolo and Laurence Turpin and Nathalie Charland and Steve G. Labbe and M. Mortier and Tim J Mitchell and Christiane M Feron and Denis Nicol{\'a}s Martin and Jan T. Poolman},
  journal={Microbiology},
  year={2011},
  volume={157 Pt 2},
  pages={
          336-48
        }
}
Restricted to the genus Streptococcus, the Pht protein family comprises four members: PhtA, PhtB, PhtD and PhtE. This family has the potential to provide a protein candidate for incorporation in pneumococcal vaccines. Based on sequence analysis and on RT-PCR experiments, we show here that the pht genes are organized in tandem but that their expression, except that of phtD, is monocistronic. PhtD, PhtE, PhtB and PhtA are present in 100, 97, 81 and 62 % of the strains, respectively, and, by… CONTINUE READING

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HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Complete genome sequence of an M1 strain of Streptococcus pyogenes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL