Transcriptional regulated plasticity of vascular contractile endothelin ET(B) receptors after organ culture.

@article{Mller1997TranscriptionalRP,
  title={Transcriptional regulated plasticity of vascular contractile endothelin ET(B) receptors after organ culture.},
  author={Sebastian M{\"o}ller and Lars Edvinsson and Mikael Adner},
  journal={European journal of pharmacology},
  year={1997},
  volume={329 1},
  pages={
          69-77
        }
}
The aim of the present study was to investigate the level of regulation of the contractile endothelin ET(B) receptor which appears spontaneously after organ culture of vascular segments. Endothelin-1 elicited a strong contraction while the selective endothelin ET(B) receptor agonist, sarafotoxin 6c, had a negligible effect on fresh ring segments of rat mesenteric artery. After organ culture in serum-free Dulbecco's modified Eagle's medium at 37 degrees C (for 1 or 2 days) the endothelin-1… CONTINUE READING
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