Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis

@article{Wang2006TranscriptionalPS,
  title={Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis},
  author={S Wang and Mei-yun Zhan and J Yin and John M. Abraham and Yuriko Mori and Fumiaki Sato and Y Xu and Andreea Olaru and Agnes T Berki and Huiying Li and Karsten Schulmann and Takatsugu Kan and James P. Hamilton and Bogdan C. Paun and May Mei-Yung Yu and Zhe Jin and Yulan Cheng and T Ito and Carmit Mantzur and Bruce D. Greenwald and Stephen J. Meltzer},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3346-3356}
}
To investigate the relationship between Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological stages of esophageal neoplasia using a sequence-verified human cDNA microarray. Fifty one RNAs, comprising 24 normal esophagi (NE), 18 BEs, and nine EACs were hybridized to cDNA microarrays. Five statistical analyses were used for the data analysis. Genes showing significantly different expression levels among the three sample… CONTINUE READING

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